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heterozygosity

C2
Rare

Pronunciation

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      Meanings

      Noun

      1. the presence or degree of different alleles at one or more gene loci

      Beyond the definition

      Imagine building with LEGO bricks. If you only have one type of brick, your creations are limited. Heterozygosity is like having a mix of different colored and shaped bricks. It means there are two different versions (called alleles) of a gene at the same place in a pair of chromosomes. Think about eye color: maybe one parent passes on a version linked to blue eyes and the other passes on a version linked to brown eyes. When the two versions are different, that gene shows heterozygosity.

      This is not just about eye color; it can apply to many genes. In a whole population, high heterozygosity often points to more genetic variety, which can help a species adjust to change. Scientists who study endangered animals pay close attention to it, because low levels can be a warning sign of inbreeding or poor genetic health.

      Examples

      1. 1

        Genetic diversity

        The researchers found high heterozygosity in the wild population, which suggested strong genetic diversity.

      2. 2

        Inbreeding

        Breeding too closely within a small group can reduce heterozygosity over time.

      3. 3

        Tumor genetics

        The pathologist looked for loss of heterozygosity in the tumor sample.

        • Domainloss of heterozygosity

          a genetic change where one of two different gene versions is lost

      See also

      Similar

      • gene diversity
      • heterozygote frequency

      Shades of meaning

      • genetic variability

      Contrast

      Used with (collocations)

      • observed heterozygosity
      • expected heterozygosity
      • loss of heterozygosity
      • heterozygosity estimate

      Word family

      Explore

      • allele
      • Hardy-Weinberg equilibrium

      Forms and spellings

      1 form open this card.

      Main spelling

      • heterozygositynoun