WordGarden.ioproline
C1Pronunciation
UK
US
Meanings
Noun
an amino acid found in proteins and important for protein structure
Beyond the definition
Proline is one of the 20 standard amino acids that living things use to build proteins. Unlike most other amino acids, it has a ring-shaped structure. That special shape gives it an important role in proteins such as collagen, which helps support skin, tendons, and other connective tissues.
Think of proteins as long chains made of small beads. This amino acid is one of those beads, but it is shaped differently from most of the others. Because of that, it can make a protein bend or hold a certain shape. It is especially common in collagen, a major protein in skin, tendons, ligaments, and cartilage.
Proline is a non-essential amino acid, which means the human body can usually make enough of it on its own. Even so, it plays an important part in the structure and function of proteins. Among the 20 standard amino acids, it stands out because its side chain loops back and joins the nitrogen in the backbone, forming a rigid five-membered ring. That stiffness affects how a protein folds and how well it keeps its shape.
This special feature makes it especially important in collagen. Collagen is the most abundant protein in mammals and helps support tissues such as skin, bones, tendons, ligaments, and cartilage. Proline, along with its related form hydroxyproline, helps stabilize collagen's triple-helix structure, which gives many body tissues their strength and resilience.
Beyond collagen, proline also affects the folding of many other proteins, which can change how those proteins work. For that reason, it matters in many normal processes in the body. It is found in many protein-rich foods, including meat, dairy products, and eggs.
Whether you meet it in biology, nutrition, or medicine, proline is best understood as a protein building block with an unusual shape. That shape makes it especially useful in collagen and in places where the form of a protein matters as much as its chemical parts.
Examples
- 1
Diet and collagen
Gelatin is rich in proline, so it often comes up in discussions of collagen.
- 2
Plant stress
The researchers measured proline levels in the plants after several days without water.
- 3
Protein structure
A single proline residue can change the shape of a protein chain.
- Domainproline residue
one proline unit inside a protein
See also
Forms and spellings
1 form open this card.
Main spelling
- prolinenoun