phage
C2Pronunciation
UK
- /fˈeɪdʒ/
US
- /ˈfeɪdʒ/
Description
- virus that infects bacteria
- bacterial virus
- bacteria eater
Imagine a tiny virus made to find and attack bacteria. That's what a phage is. Unlike the viruses that make people sick, this kind targets bacterial cells. It attaches to a bacterium, puts its genetic material inside, and uses the cell's machinery to make more copies. In many cases, the bacterium then breaks open and releases the new viruses.
These viruses are found almost everywhere, including soil, water, and the human gut. Scientists are also studying them as a possible way to fight harmful bacteria, especially as antibiotic resistance becomes a bigger problem. The word comes from Greek and means "to eat," which fits the way they attack bacteria.
A phage, short for bacteriophage (meaning "bacteria eater"), is a virus that specifically infects and reproduces inside bacteria. While we often think of viruses as causing diseases in plants or animals, phages are extremely common and play an important role in controlling bacterial populations in the environment, from oceans to soil to our own bodies.
Phages come in many shapes. Some have a head-and-tail form that looks a bit like a tiny lander, while others are simpler in structure. They work by attaching to the surface of a bacterium and injecting their genetic material, which may be DNA or RNA, into the cell. The infected cell then becomes a factory for making new viral particles until it bursts open in the lytic cycle, releasing more viruses to infect other bacteria. Some can also insert their DNA into the bacterium's genome in the lysogenic cycle, staying inactive for a time before becoming active again.
The discovery of phages dates back to the late 19th and early 20th centuries, but their medical potential has drawn much more attention in recent years. As antibiotic resistance becomes a more serious problem, scientists are exploring phage therapy, which uses these viruses to treat bacterial infections, as a possible alternative or partner to antibiotics. One reason for this interest is that phages are often highly specific, meaning they target certain bacteria without affecting many others.
So, although you cannot see them, these tiny viruses are always present around us, shaping the microbial world and offering a possible tool for modern medicine. They are a striking example of how even viruses can sometimes be useful.
Examples
- 1
Lab culture
The lab added a phage to the bacterial culture and watched the cells break apart.
- 2
Medical treatment
Some doctors are studying phage therapy for infections that no longer respond to antibiotics.
Domain
phage therapy
treatment that uses phages against bacterial infections
- 3
Bacterial resistance
Bacteria can become resistant to certain phages, just as they can become resistant to drugs.
Forms and spellings
1 form open this card.
Main spelling
- phagenoun