WordGarden.ioligation
C2Pronunciation
UK
US
- /laɪˈɡeɪʃən/
Meanings
Noun
the surgical tying off of a blood vessel, duct, or similar body channel
the joining of DNA or other biological molecules into a single chain
Beyond the definition
Ligation isn't something you do with yarn and knitting needles—though it does involve tying things together! It is a medical procedure where tissues or blood vessels are closed or tied off, usually with sutures. Think of a surgeon carefully ligating a bleeding artery to stop the flow of blood.
But ligation isn't limited to surgery. In biochemistry, it also means joining molecules together, such as pieces of DNA. So, while you might not hear the word in daily life, it appears often in labs and hospitals. The term comes from the Latin word ligare, meaning "to bind." If a plumber ties off a leaking pipe, the idea is similar—though they certainly wouldn't call it ligation!
Ligation refers to the process of tying off or binding something securely, or in some scientific settings, joining parts together. The term is most commonly used in medical and biological contexts.
In surgery, ligation is a vital technique used to control bleeding or close a passage by tying off blood vessels or ducts with suture material. For example, during an appendectomy, surgeons ligate the arteries supplying the appendix before removing the organ. It is also used in procedures like tubal ligation or ligating the bile duct during gallbladder removal. In these instances, the term implies a secure and often permanent closure.
Beyond the operating room, ligation is a cornerstone of molecular biology. It describes a key step in genetic engineering where DNA fragments are joined together using an enzyme called DNA ligase. This process allows scientists to create recombinant DNA molecules, essentially "cutting and pasting" genes to study them or use them in research and medicine.
You may also see the word in chemistry, though this is less common in everyday use. Across these fields, ligation is about making a firm connection, either by closing something off or by joining separate parts into one.
Examples
- 1
Surgical bleeding
The surgeon stopped the bleeding by ligation of the damaged artery.
- 2
Birth control
After their second child, she decided to have a tubal ligation.
- Domaintubal ligation
an operation that prevents pregnancy by closing the fallopian tubes
- 3
Medical monitoring
The nurse checked the ligation site for redness and swelling.
- 4
Genetics lab
In the genetics lab, DNA ligation was the final step before the sample could be tested.
- DomainDNA ligation
joining pieces of DNA together
See also
Forms and spellings
1 form open this card.
Main spelling
- ligationnoun