WordGarden.iointegrin
Pronunciation
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Meanings
Noun
a cell-surface receptor protein involved in cell adhesion and signaling
Beyond the definition
Imagine cells as tiny living parts that need to hold on to their surroundings and react to what is happening around them. Integrins are proteins on the cell surface that do both jobs. They help a cell attach to the material around it, and in some cases to other cells, acting like a link between the outside world and the inside of the cell. Without them, tissues would not form well, cells would not move in the right way, and wounds would heal poorly.
These proteins do more than help cells stay in place. They also pass signals into the cell, letting it respond to pressure, movement, damage, or nearby molecules. That makes them important in growth, immune defense, and repair. They also matter in disease, because cancer cells can use them to move and spread. You are most likely to see this word in biology or medical writing rather than in everyday conversation.
Integrins are a family of transmembrane proteins, which means they pass through the cell membrane and connect the inside of a cell with the world outside it. They help cells attach to the extracellular matrix, the supportive material around cells, and in some cases to other cells. But they are not just passive glue. They also help cells sense their environment and respond to it.
These proteins are essential in many biological processes. During development, they help guide cell movement and tissue formation. In the immune system, they help white blood cells attach to blood vessel walls so they can leave the bloodstream and reach infected tissue. They are also important in wound healing, helping cells move into damaged areas and rebuild tissue.
Integrins also have an important role in disease. Cancer cells can use integrin-related signaling to survive, invade nearby tissue, and spread to other parts of the body. Because of this, they have become an important target in medical research. Scientists study ways to block certain integrins in order to limit harmful cell attachment or movement.
The name comes from the idea of integration: these proteins help combine outside signals with events inside the cell. In that sense, they are both anchors and messengers. While the word usually appears in biology, medicine, and research rather than in everyday speech, it is a key term for understanding how cells hold together, move, communicate, and take part in health and disease.
Examples
- 1
Cell surface
The lab measured how much of this integrin was present on the surface of each cell.
- 2
Cancer treatment
Some cancer drugs are designed to block certain integrins, which may help slow tumor spread.
- 3
Research paper
The paper focuses on integrin-mediated adhesion between cells and the material around them.
- Phraseintegrin-mediated
happening through integrins
See also
Shades of meaning
- adhesion receptor
Contrast
- soluble receptor
Used with (collocations)
- integrin signaling
- integrin-mediated adhesion
- integrin ligand
- integrin activation
Word family
- integrins
Explore
- cell adhesion molecule
- extracellular matrix
Forms and spellings
1 form open this card.
Main spelling
- integrin