contig
Pronunciation
UK
US
Meanings
Noun
a contiguous DNA sequence assembled from overlapping fragments
Beyond the definition
Imagine building with LEGOs. If you snap several bricks together in a line to create one long, unbroken piece, you have created the equivalent of a contig! In biology, a "contig" is a set of overlapping DNA sequences that have been put together into one continuous stretch. It's all about small pieces being joined to form one larger piece. The word is a shorthand for "contiguous" (meaning connected with no gaps), and a contig is the finished result. Think of a string of pearls: the entire connected string represents a contig, while each individual pearl is a piece that helped form the whole.
A contig (short for "contiguous sequence") is a technical term used primarily in genomics and bioinformatics. While you might use the adjective contiguous to describe things that touch or run together—like "houses built contiguously along a street"—a contig is the noun for the single, continuous block formed when overlapping pieces are combined.
In genetics, a contig is a DNA sequence where overlapping fragments have been assembled to create a longer, uninterrupted stretch of genetic code. Think of it like piecing together a jigsaw puzzle: each fragment is a small piece of the genome, and when the pieces overlap and connect, they form a larger, more complete picture—that's your contig. Scientists use contigs as essential building blocks for assembling entire genomes. The longer and more reliable a contig is, the more confident scientists can be in the accuracy of their genetic map.
Outside DNA work, you may also see contig used more loosely for a single continuous span created from smaller pieces (for example, in some computing contexts). However, it is important to remember the distinction: if you are describing the state of being adjacent or unbroken, use contiguous. If you are referring to the resulting unified sequence or segment itself, you are talking about a contig—a seamless joining of parts into one continuous whole.
Examples
- 1
DNA assembly
After assembling the DNA reads, the software produced a single contig for the whole gene.
- Domaincontig
a continuous DNA sequence made by joining overlapping shorter pieces
- 2
Incomplete genome
This sample gave many short contigs, so the researchers still could not rebuild the complete genome.
- 3
Reference comparison
The team compared each contig with a reference genome to see where it fit.
See also
Forms and spellings
1 form open this card.
Main spelling
- contig